The carboxylic acid group of quinolones was modified; so. we designed new quinolones derivatives with different antioxidants using Ligand Designer from Glide (Schrodinger LLC). The cap group and the linker were optimized through trying various aliphatic and aromatic residues. A new synthesized derivatives (IIa-Vb) were synthesized by esterification of (ciprofloxacin. https://globechemicalcompanyls.shop/product-category/kor-chem/