Abstract Polo-like kinase 1 (PLK1). a serine/threonine kinase. is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB. https://countryscenesaddleryandpetsuppliers.shop/product-category/hair-on-cowhide-headstall-and-breast-collar-sets/